I-Atomoxetine umuthi osebenza ngokwengqondo osetshenziswa kabanzi ekwelapheni ukunakwa kwe-attention deficit hyperactivity disorder (ADHD). Isebenza njenge-norepinephrine reuptake inhibitor ekhethiwe, ikhulisa amazinga ale neurotransmitter ebuchosheni futhi isize ukuthuthukisa ukunaka, ukugxila, nokulawula umfutho ezigulini ezine-ADHD. Ukwengeza, i-atomoxetine nayo iye yafundwa futhi yasetshenziswa ekwelapheni ezinye izifo zengqondo, njengokuphazamiseka kokukhathazeka nokucindezeleka. Kodwa-ke, kubalulekile ukugcizelela ukuthi i-atomoxetine ingabangela imiphumela emibi futhi kufanele isetshenziswe kuphela ngaphansi kwencwadi yezokwelapha kanye nokuqapha okufanele.
Izinkomba zomuthi i-atomoxetine: ukuthi ingeyani nokuthi isebenza kanjani ekwelashweni.
I-Atomoxetine umuthi osebenza ngokwengqondo ngokuyinhloko osetshenziselwa ukwelapha I-Attention Deficit Hyperactivity Disorder (ADHD) ezinganeni, intsha, kanye nabantu abadala. Ingase futhi imiselwe i-narcolepsy, ukuphazamiseka kokulala okubangela ukulala ngokweqile emini.
I-Atomoxetine isebenza ngokuvimbela ngokukhetha ukuphindaphinda kwe-norepinephrine, ngaleyo ndlela ikhulise ukutholakala kwale neurotransmitter ebuchosheni. Lokhu kusiza ukuthuthukisa ukugxilisa ingqondo, ukunaka, nokulawula umfutho, izici ezivame ukuthinteka ezigulini ezine-ADHD.
Kubalulekile ukuqaphela ukuthi i-atomoxetine ayiyona i-psychostimulant, ngokungafani ne-methylphenidate, enye imithi evame ukusetshenziselwa ukwelapha i-ADHD. Ngakho-ke, kungase kube inketho ezigulini ezingaphenduli kahle kuzikhuthazi noma ezinokuphikisana nokusetshenziswa kwazo.
Imiphumela emibi kakhulu ye-atomoxetine ihlanganisa isicanucanu, ukozela, isiyezi e ukulahlekelwa ukudla. Ezimweni ezingavamile, ukwanda komfutho wegazi e imicabango yokuzibulala. Ngakho-ke, kubalulekile ukulandela iseluleko sezokwelapha futhi ubike noma yiziphi izimpawu ezimbi ngesikhathi sokwelashwa.
I-Atomoxetine: ukutholakala eBrazil kanye nolwazi mayelana nomuthi.
I-Atomoxetine umuthi osebenza kwengqondo osetshenziselwa ukwelapha i-Attention Deficit Hyperactivity Disorder (ADHD). E-Brazil, i-Atomoxetine itholakala emakhemisi ngencwadi kadokotela futhi imakethwa ngaphansi kwegama lomkhiqizo IStrattera.
I-Atomoxetine isebenza ebuchosheni ngokwandisa ukugcwala kwama-neurotransmitters njenge-norepinephrine. Lokhu kusiza ukuthuthukisa ukunaka, ukulawula okungalindelekile, kanye nokunganyakazi kahle ezigulini ezine-ADHD. Ukwengeza, i-atomoxetine iyindlela ehlukile yalabo abangaphenduli kahle kwizikhuthazi zendabuko ze-ADHD.
Imiphumela emibi evame kakhulu ye-atomoxetine ihlanganisa isicanucanu, isiyezi, ukozela, nokuncipha kwesifiso sokudla. Kubalulekile ukugcizelela ukuthi i-atomoxetine kufanele isetshenziswe ngaphansi kwencwadi kadokotela kanye nokugadwa kochwepheshe, njengoba ingabangela imiphumela emibi kwabanye abantu.
Ukusetshenziswa kwayo kufanele kwenziwe ngokuqapha nangaphansi kokuqondisa kodokotela ukuze kuqinisekiswe ukusebenza kahle nokuphepha kokwelashwa.
Thola ukwelashwa kwe-ADHD okuthuthuke kakhulu okutholakala emakethe namuhla.
I-Atomoxetine umuthi osebenza kwengqondo osetshenziselwa ukwelapha i-Attention Deficit Hyperactivity Disorder (ADHD). Lo muthi usebenza njenge-norepinephrine reuptake inhibitor ekhethiwe, enikeza umphumela ohlala njalo uma kuqhathaniswa neminye imithi ngenjongo efanayo.
Imiphumela ye-Atomoxetine ihlanganisa ukunakwa okuthuthukisiwe, ukuncishiswa kokusebenza ngokweqile kanye nokungasukumi, futhi ngenxa yalokho, izinga lempilo elingcono leziguli ezine-ADHD. Ngaphezu kwalokho, lo muthi awukhuthazi, okwenza ube inketho ephephile kulabo abangaphenduli kahle kwizikhuthazi zendabuko.
Njengamanje, i-Atomoxetine ithathwa njengenye yezindlela zokwelapha ezithuthuke kakhulu ze-ADHD ezitholakala emakethe. Ukusebenza kwayo nokusebenza isikhathi eside kwenza kube ukukhetha okudumile phakathi kodokotela neziguli.
Uma wena noma othile omaziyo ehlushwa i-ADHD, thintana nodokotela ukuze ubone ukuthi i-Atomoxetine iyindlela yokwelapha engcono kakhulu kuwe. Lo muthi unganikeza izinzuzo ezibalulekile futhi uthuthukise ikhwalithi yempilo yalabo ababhekene nezimpawu ze-ADHD.
Yimuphi umuthi osebenza kakhulu ekwelapheni i-ADHD nokukhathazeka?
I-Atomoxetine umuthi ovame ukusetshenziselwa ukwelapha i-Attention Deficit Hyperactivity Disorder (ADHD) futhi ungase uphumelele ekwelapheni ukukhathazeka. Ngokungafani neminye imithi evame ukunikezwa lezi zinkinga, njengezikhuthazi, i-Atomoxetine ayibhekwa njengesidakamizwa esisebenza kwengqondo.
I-Atomoxetine isebenza njenge-norepinephrine reuptake inhibitor ekhethiwe, esiza ukulawula ukusebenza kobuchopho futhi ithuthukise izimpawu ze-ADHD nokukhathazeka. Lo muthi ungaba inketho ephephile kulabo abangaphenduli kahle kuzivuseleli noma abakhathazeke ngokuthi kungenzeka yini ukuhlukumeza.
Ucwaningo luye lwabonisa ukuthi i-atomoxetine ingasebenza ngempumelelo ekwelapheni i-ADHD nokukhathazeka kubantu abadala nasezinganeni. Imiphumela emibi evame kakhulu ihlanganisa ikhanda elibuhlungu, isicanucanu, nokozela, kodwa ngokuvamile ziba mnene futhi ziyanyamalala ngokuhamba kwesikhathi.
Hlala uthintana nochwepheshe bezempilo ngaphambi kokuqala noma yikuphi ukwelashwa ngalo muthi.
I-Atomoxetine: Imiphumela kanye nokusetshenziswa kwalo Muthi Osebenza Ngengqondo
Ukwelashwa kokuphazamiseka kwengqondo okuhlukahlukene kungatholwa ngezindlela eziningi. Enye ihilela ukuguqula amakhemikhali obuchopho ngokusebenzisa izidakamizwa ze-psychotropic, okuholela ekunciphiseni kwezimpawu.
Imithi eminingi ye-psychotropic yahlanganiswa ngenkinga ethile engqondweni, kodwa izindlela zayo zokusebenza ngokuvamile zisebenza ngempumelelo enkingeni engaphezu kweyodwa. I-Atomoxetine ingenye yomkhiqizo onjalo , ozothola incazelo emfushane ngayo kulesi sihloko.
Iyini i-atomoxetine?
I-Atomoxetine iyisidakamizwa esisebenza ngengqondo esenziwe njenge-antidepressant esebenza njenge-inhibitor ethile ye-norepinephrine reuptake. Kuyinto etholakala ku-methylphenoxybenzenepropanamine enemiphumela efana naleyo ye-norepinephrine ne-adrenaline.
Imiphumela yale nto ihumushela ku ukwanda kwekhono lokulawula ukuziphatha okungalindelekile kanye nekhono elikhulayo lokugxila. Kubonakala futhi kuthuthukisa umthamo wenkumbulo yokusebenza kanye nokuvimbela impendulo, nemiphumela emihle emisebenzini yokuphatha.
Ibuye ibe nomphumela we-nootropic. , ukusiza ukugcina ukugxilisa ingqondo nokunikeza impendulo engcono ezingeni lokuqonda, okukhiqiza imiphumela emihle ekukhunjweni kwenkumbulo nokuthuthukiswa kwamasu.
- Ungase ube nesithakazelo: "Ama-Nootropics: Ayini futhi athuthukisa kanjani ukuhlakanipha kwakho?"
Indlela yokwenza
Njengoba sishilo ngaphambili, i I-atomoxetine iyi-SNRI noma i-norepinephrine ethile noma i-norepinephrine reuptake inhibitor. Lokhu kusho ukuthi ivimbela i-norepinephrine ekubeni iphinde imunywe yi-presynaptic neuron ngemva kokuphuma, ukuze i-neurotransmitter ihlale itholakala endaweni ye-synaptic futhi ingasetshenziswa yi-postsynaptic neuron. Ngamafuphi, umphumela oyinhloko we-atomoxetine ukwandisa amazinga e-norepinephrine, njenge-agonist ingxenye.
I-Atomoxetine isebenza ezingeni lobuchopho obuphelele, nemithelela ebonakala ezindaweni ezifana ne-hypothalamus, i-hippocampus, i-cerebellum, ne-prefrontal cortex. Lokhu kuvinjwa kwe-reuptake kucace kakhulu ku-norepinephrine futhi ayithinti i-serotonin noma i-dopamine, nakuba esimweni sokugcina kukhona ukwanda kwe-prefrontal. Kubonakala futhi ukwandisa amazinga e-acetylcholine.
- Ungase ube nesithakazelo: ” Izinhlobo zama-antidepressants: izici nemiphumela “
Ukusetshenziswa okuyinhloko kwe-atomoxetine
Nakuba nginayo yakhelwe njenge-antidepressant ngenhloso yokuphatha abantu abane-depressive disorders , i-atomoxetine ngokuvamile ayisetshenziselwa lolu hlobo lwenkinga ngenxa yokuphumelela okukhulu kwezinye izinto.
Ukusetshenziswa kwayo okuyinhloko, futhi okuye kwaphumelela kakhulu, isekwelashweni kwemithi yeziguli ezine-ADHD Kodwa-ke, akuwona umuthi we-psychostimulant, njengemithi eminingi elapha lesi simo. Eqinisweni, ingeyokuqala engakhuthazi i-psychopharmaceutical evunyelwe futhi ekhonjiswe ukwelashwa kokuphazamiseka kokunaka kokungasebenzi kahle.
Lokhu kuhle, njengoba iziguli ezinalesi sifo zingase zibe nezinkinga ze-comorbid tic, ezingabhebhethekiswa imithi evuselelayo (ukwelashwa okuyinhloko kwemithi kubantu abane-ADHD). Ngakho-ke, i-atomoxetine ingaba ukwelashwa okuphumelelayo kakhulu ukuthi, ngenxa yokuthi akuyona into evuselelayo, ayiqhubeki izimpawu ze-tic. Imiphumela ezuzisayo ibonakala kokubili ezinganeni nakubantu abadala.
Ibuye ikhonjiswe ezimweni ze-narcolepsy.
- Ungase ube nesithakazelo kulokhu: ” I-Attention Deficit Hyperactivity Disorder (ADHD), nakubantu abadala “
Okuqhamuka uma udla imishanguzo
Njengayo yonke imithi, I-atomoxetine ingabangela imiphumela emibi eminingana engathandeki Ubukhulu balezi zimpawu zesibili bungahluka, kodwa ngokuvamile bumnene.
Ezinye ezivame kakhulu i-anorexia (eqondwa njengokuntula ukudla), ukuncipha kwesisindo okuhlobene nalokhu okungenhla, izinkinga zamathumbu ezinjengokucanuzela kwenhliziyo nokuhlanza, ukucasuka nokozela Kubantu abadala, kungase futhi kubangele ukujuluka nokulahlekelwa isifiso sobulili, kanye nokugcinwa komchamo nendle.
Ezingeni le-cardiovascular, kungase futhi kubangele izinguquko, ukwandisa umfutho wegazi kanye nenhliziyo. Ngakho-ke, i-contraindicated kubantu abanezimo zenhliziyo. Akunconywa futhi ngesikhathi sokukhulelwa noma ukuncelisa. .
Kodwa-ke, umphumela okhathazayo kakhulu owabiwe namanye ama-antidepressants ukwanda kwemibono yokuzibulala ezinganeni, kanye nolaka, ukukhathazeka noma ukushintsha kokuziphatha noma kwemizwelo . Izinyathelo zokuqapha ziyadingeka, ikakhulukazi uma ukwelashwa kuqala noma umthamo ushintshiwe.
Izinkomba ze-Bibliographic:
- De Lucas, M.T. kanye no-Montañés, F. (2007). I-Atomoxetine: izibani nezithunzi. I-Biological Psychiatry, i-14; 13-23. Elsevier Madrid