I-5-Hydroxytryptophan (5-HTP) iyi-amino acid yemvelo ekhiqizwa umzimba nge-tryptophan, etholakala ekudleni okufana nenyama, ubisi, namantongomane. Iyisandulela se-serotonin ye-neurotransmitter, edlala indima ebalulekile ekulawulweni kwemizwa, ukulala, kanye nesifiso sokudla. I-5-HTP ivame ukusetshenziswa njengesengezo sokwelapha ukuphazamiseka kwemizwelo okunjengokucindezeleka nokukhathazeka, kanye nokuthuthukisa ukulala nokulawula ukudla. Nokho, kubalulekile ukubonana nochwepheshe bezempilo ngaphambi kokuqala i-5-HTP, njengoba ingasebenzisana neminye imithi futhi ibangele imiphumela emibi engadingeki.
I-5-HTP: thola ukuthi siyini lesi sithasiselo semvelo nokuthi senzani.
I-5-HTP, noma i-5-hydroxytryptophan, iyisengezo semvelo esitholakala esitshalweni sase-Afrika esibizwa nge-Griffonia simplicifolia. Le nto i-amino acid esebenza njengesandulela se-serotonin, i-neurotransmitter ebalulekile ekulawuleni isimo, ukulala, kanye nesifiso sokudla.
I-5-HTP isetshenziswe njengendlela engokwemvelo yokwelapha ukudangala, ukukhathazeka, ukuqwasha, ngisho nokusiza ukwehlisa isisindo. Ngokwandisa amazinga e-serotonin ebuchosheni, lesi sengezo singasiza ukuthuthukisa isimo sengqondo, ukunciphisa ukukhathazeka, futhi sikhuthaze ukulala okuzolile.
Ngaphezu kwalokho, i-5-HTP ingasetshenziswa futhi ukulawula izifiso zokudla kanye nesifiso sokudla amaswidi, njengoba i-serotonin ihlobene nemizwa yokusutha kanye nenhlalakahle. Ngakho-ke , lesi sithasiselo singaba inketho ethokozisayo kulabo abafuna ukuthuthukisa impilo yabo yengqondo nengokomzwelo ngokwemvelo.
IHydroxytryptophan: umqondo kanye nokusetshenziswa empilweni nasenhlalakahleni yomzimba womuntu.
I-Hydroxytryptophan, eyaziwa nangokuthi i-5-hydroxytryptophan (5-HTP), iyi-amino acid eyenzeka ngokwemvelo ekhiqizwa umzimba nge-tryptophan. Lesi sici sidlala indima ebalulekile ekukhiqizweni kwe-serotonin, i-neurotransmitter elawula isimo sengqondo, ubuthongo kanye nesifiso sokudla.
I-Hydroxytryptophan (5-HTP) ivame ukusetshenziswa njengesengezo sokuthuthukisa impilo yengqondo kanye nenhlalakahle yemizwa. Ihlotshaniswa nezinzuzo ezifana nokuthuthukiswa kwemizwa, ukuncipha kokukhathazeka, kanye nokulawula isifiso sokudla. Ngaphezu kwalokho, i-5-HTP ingasetshenziswa futhi ekwelapheni ukucindezeleka, ukuqwasha, kanye ne-migraines.
Izifundo zibonisa ukuthi i-hydroxytryptophan ingasebenza kahle ekwelapheni izifo ezihlobene ne-serotonin, isize ekulinganiseni amazinga ale neurotransmitter ebuchosheni. Kungaba yindlela yemvelo ehlukile kunemithi yokucindezeleka yendabuko kanye nemithi yokukhathazeka, enemiphumela emibi embalwa.
Kubalulekile ukugcizelela ukuthi, njenganoma yisiphi isithasiselo, ukusetshenziswa kwe-Hydroxytryptophan kufanele kwenziwe ngaphansi kokuqashwa kwezokwelapha. Kungasebenzisana neminye imithi futhi kubangele imiphumela emibi kwabanye abantu. Ngakho-ke, kubalulekile ukubonisana nochwepheshe wezempilo ngaphambi kokuqala ukusebenzisa lesi sidakamizwa.
Imiphumela emibi ye-5-HTP: yini ebalulekile ukwazi ngayo.
I-5-hydroxytryptophan, noma i-5-HTP, iyisengezo semvelo esisetshenziselwa kabanzi ukwelapha izimo ezihlukahlukene, njengokucindezeleka, ukukhathazeka, ukuqwasha, kanye nemigraines. Kodwa-ke, njenganoma iyiphi enye into, i-5-HTP ingabangela imiphumela emibi kwabanye abantu.
Eminye yemiphumela evame kakhulu ye-5-HTP ihlanganisa isicanucanu, ubuhlungu besisu, isifo sohudo, nesiyezi. Lezi zimpawu ngokuvamile ziba mnene futhi ziyanyamalala ngokuhamba kwesikhathi njengoba umzimba ujwayela into ethile. Kodwa-ke, ezimweni ezingavamile, kungase kube nemiphumela emibi kakhulu, njengokushaya kwenhliziyo, ukubona izinto ezingekho, kanye nesifo se-serotonin.
Kubalulekile ukuqaphela le miphumela engemihle engenzeka lapho uthatha i-5-HTP futhi uhlale uthintana nochwepheshe wezokunakekelwa kwempilo ngaphambi kokuqala noma yiziphi izithasiselo. Ngaphezu kwalokho, kubalulekile ukulandela imiyalelo yomthamo ngendlela efanele futhi ungeqi inani elinconyiwe ukuze ugweme ukusabela okungekuhle.
Njalo thintana nodokotela ngaphambi kokuqala noma yisiphi isithasiselo esisha futhi uqaphele izimpawu zokungaphatheki kahle okungenzeka.
Ingabe kuphephile ukuthi abantu abane-ADHD bathathe i-5-HTP?
I-5-hydroxytryptophan (5-HTP) iyisengezo semvelo esitholakala embewini yesitshalo se-Griffonia simplicifolia. Isetshenziselwa ukwandisa amazinga e-serotonin ebuchosheni, engasiza ukulawula isimo sengqondo, ukulala, kanye nesifiso sokudla.
Kubantu abane-ADHD, ukusetshenziswa kwe-5-HTP kungaba yimpikiswano. Olunye ucwaningo lubonise ukuthi ukwesekwa kwe-5-HTP kungathuthukisa izimpawu ze-ADHD ezifana nokungabi nangqondo kanye nokungasebenzi kahle. Nokho, ezinye izifundo azitholanga izinzuzo ezibalulekile.
Ngaphezu kwalokho, kukhona ukukhathazeka ngokuphepha kokusebenzisa i-5-HTP kubantu abane-ADHD. Olunye ucwaningo lubonisa ukuthi i-5-HTP ingasebenzisana nemithi ethile esetshenziselwa ukwelapha i-ADHD, okungase kwandise imiphumela emibi.
Ngakho-ke, ngaphambi kokuqala ukuthatha i-5-HTP ye-ADHD, kubalulekile ukubonisana nodokotela noma uchwepheshe wezempilo ofanelekayo. Bazokwazi ukuhlola isimo sakho futhi banqume ukuthi i-5-HTP iphephile futhi ikufanele yini.
I-5-hydroxytryptophan (5-HTP): izici nokusetshenziswa kwale nto
I-5-Hydroxytryptophan, noma i-5-HTP, iyisandulela esibalulekile somzimba womuntu sokwakha i-serotonin, i-neurotransmitter yobuchopho. Le khompawundi ikhulisa amazinga e-serotonin ebuchosheni. Okwamanje, i-serotonin idlala indima ebalulekile emzimbeni, ithwala izimpawu phakathi kwama-neurons ohlelweni lwezinzwa.
Kulesi sihloko, sizobheka ukuthi iyini ngempela i-5-hydroxytryptophan futhi sifunde ngokusetshenziswa kwayo, imiphumela engemihle, nokusebenza kwayo.
I-5-Hydroxytryptophan: izici
I-5-Hydroxytryptophan (5-HTP) yaziwa nangokuthi i-oxitriptan (INN). Iyi -amino acid eyenzeka ngokwemvelo kanye nesandulela samakhemikhali futhi iphakathi kokwenziwa kwe-neurotransmitter serotonin kanye ne-melatonin evela ku-tryptophan.
Njengoba sesibonile, i-5-hydroxytryptophan yandisa amazinga e-serotonin ebuchosheni futhi ithuthukisa izimpawu zezinye izimo, njengokucindezeleka.
Ngokuqondene nokuthengiswa kwayo, i-5-hydroxytryptophan noma i-5-HTP ithengiswa njengesengezo sokudla e-United States naseCanada, ngezenzo ezifana ne-antidepressant, i-appetite suppressant futhi isiza ngokulala nokulala.
Ibuye ithengiswe emazweni amaningi aseYurophu njenge-antidepressant, ngaphansi kwamagama okuhweba alandelayo: I-Cincofarm, i-Levothym, i-Levotonine, i-Oxyfan, i-Telesol, i-Tript-OH ne-Triptum.
Ngokuphathelene nokusebenza kwayo ekwelapheni ukucindezeleka, izivivinyo eziningana zomtholampilo ezingaboni kabili zibonise ukusebenza kwe-5-hydroxytryptophan. Kodwa-ke, izinga lalezi zifundo liye labatshazwa.
- Ungase ube nentshisekelo ku-: "Serotonin: Imiphumela ye-6 yale hormone emzimbeni nasengqondweni"
Sebenzisa
I-5-hydroxytryptophan isetshenziswa njengesengezo sokwelapha . Lesi sithako asitholakali ekudleni ngobuningi obukhulu. Ngokukhethekile, siyisithako esiphakathi esihlanganyela ekugayweni kwe-tryptophan.
Ngaphezu kwalokho, i-tryptophan iyi-amino acid ebalulekile ekudleni kwabantu, etholakala ekudleni okufana ne-turkey, ubisi, amazambane, ithanga, kanye nemifino ehlukahlukene.
I-5-Hydroxytryptophan ivamise ukuthengiswa njengesengezo sokudla futhi itholakala embewini ye-legume Griffonia simplicifolia (isitshalo sase-Afrika). Ivamise ukuthengiswa ku-50 mg noma 100 mg yemifino noma amaphilisi e-gelatin.
Ukusebenza kahle
Ucwaningo oluningana lubonise umphumela omuhle we-5-hydroxytryptophan noma i-5-HTP ezifweni ezifana ne-fibromyalgia eyinhloko, i-Friedreich's ataxia, ikhanda elibuhlungu elingapheli (eliyinhloko noma elingaphelele), ukucindezeleka, ukukhathazeka, ukudla okuphoqelekile okuhlobene nokukhuluphala, kanye nokungalali.
Izingozi nemiphumela emibi
Nakuba i-5-hydroxytryptophan ihloliwe, ayizange ifundwe ngokujulile endaweni yokwelapha ; lokhu kusho ukuthi imiphumela emibi engaba khona kanye nokusebenzisana neminye imithi akwaziwa kahle.
Ngakolunye uhlangothi, i-5-hydroxytryptophan iye yabonwa ezilwaneni zokuhlola ukwandisa ingozi yesifo se-valve yenhliziyo. Nakuba i-5-hydroxytryptophan ingazange ibe ngaphansi kwephrothokholi yokuhlola efanayo, kuyaziwa ukuthi ukuguqulwa kwayo ku-serotonin kungabangela ukulimala okufanayo kwenhliziyo.
Ukwengeza, i-5-hydroxytryptophan elawulwa ngomlomo ingase ibangele ukwanda kwe-urinary 5-HIAA. Lena i-metabolite ye-serotonin futhi ibonisa ukuthi i-5-hydroxytryptophan i-peripherally metabolized to serotonin bese i-metabolized ku-5-HIAA.
Lokhu kungabangela i-positive engamanga ezivivinyweni ezifuna i-carcinoid syndrome . Lesi sifo sibangelwa kakhulu ukukhiqizwa kwe-serotonin ne-kallikrein futhi sihilela isethi yezimpawu ezenzeka ngemuva kwesimila se-carcinoid. Ngaphezu kwalokho, kufaka phakathi ukuhlanza, uhudo, kanye, kaningi, ukwehluleka kwenhliziyo kanye ne-bronchospasm.
Uphenyo
Olunye ucwaningo luye lwazama ukuhlaziya ukusebenza kahle, ukuphepha, nokwamukelwa kwe-5-hydroxytryptophan ne-tryptophan ekwelapheni ukucindezeleka kwe-unipolar kubantu abadala.
Imiphumela yalezi zifundo ikhombisile ukuthi izimpawu zokucindezeleka zingancipha uma i-5-hydroxytryptophan kanye ne-tryptophan ziqhathaniswa ne-placebo. Ngakolunye uhlangothi, ziphinde zibandakanye nemiphumela ethile emibi (esizoyibona ngokuningiliziwe kamuva), futhi zifaka phakathi izimpawu ezifana nesiyezi, isicanucanu, kanye nesifo sohudo.
Ngaphezu kwalokho, kwezinye izimo, i-tryptophan iye yaxhunyaniswa nesifo esibulalayo. Nokho, ubufakazi obengeziwe buyadingeka ukuze kuhlolwe ukusebenza kahle nokuphepha kwale mikhiqizo ngaphambi kokuba kuthathwe iziphetho eziqinile.
Njengamanje, maqondana nemithi, imithi yokucindezeleka isalokhu iyindlela yokuqala yokwelapha ukucindezeleka.
Ngokusobala, okutuswa kakhulu yilezo ezingenayo imiphumela emibi esongela ukuphila.
Izinkomba ze-Bibliographic:
- Shaw, K., Turner, J. kanye noDel Mar, C. (2002). I-Tryptophan ne-5-hydroxytryptophan yokucindezeleka. I-Cochrane
- Stahl, SM (2002). I-psychopharmacology ebalulekile. Izisekelo ze-Neuroscientific kanye nezicelo zomtholampilo. Barcelona: Ariel.